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Kaynaklar Forman HJ, Zhang H, Rinna A

A phase 2 clinical trial assessing the efficacy and safety of pembrolizumab and radiotherapy in patients with metastatic triple-negative breast cancer

ROS may also mediate metabolism reprogramming ( Classical strategies include direct/indirect HIF targeting and interference in upstream/downstream HIF regulators/signaling pathways

Since there was no significant difference of the mRNA level of GCS-HS and GS between control and proline group at any time points, it can be assumed that the activity of GCS in proline group might be upregulated by the upregulation of regulatory subunit of GCS, leading to the significant upregluation of total GSH from 6 h to 12 h

Given the absence of disease-modifying therapies that meaningfully slow disease progression, supportive care remains the mainstay of treatment for patients with ALS