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Additionally, this cysteine autoxidation reaction, catalyzed by transition metal ions, generates oxygen free radicals and hydrogen peroxide
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Mol Endocrinol (2003) 17(5):96775.10.1210/me.2002-0261 50 BrownRJAdamsJJPelekanosRAWanYMcKinstryWJPalethorpeKet alModel for growth hormone receptor activation based on subunit rotation within a receptor dimer

These effects are associated with increased ROS and MDA levels, as well as modifications in ferroptosis-related markers, such as Fe 2+ , SLC7A11, and GPX4 (Yang et al., 2024c)