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Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

10.1097/00003086-199704000-00029 60 KeremiB.LohinaiZ.KomoraP.DuhajS.BorsiK.Jobbagy-OvariG.et al (2009)

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Lancet 374 , 12431251 (2009)