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Originally developed in the 1990s, as a fat burning (lipolytic) compound, AOD9604 stimulates the breakdown or destruction of fat cells (lipolysis) and inhibits the metabolic formation of fat (lipogenesis) in animal studies

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[33] demonstrated that NNMT expression is upregulated in WAT of humans with insulin resistance or T2D and that plasma MNA levels are significantly and positively correlated with NNMT expression in WAT and with the degree of insulin resistance