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Research by Liu and colleagues has shown that in diabetic rat models, hyperglycemia induces the secretion of GMFB by Mller cells, and elevated levels of GMFB can impair retinal function by altering the quantity and connectivity of RPE cells (207)

53 , 54 Haroon Khan et al 55 have extensively discussed the improved bioavailability of flavonoid nano-drugs and their safety implications

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Moreover, many other cellular injuries and cell death as both apoptosis and necrosis may occur