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Similarly to hypertension, coronary artery disease, and cancer, allergies have been classified as lifestyle diseases ( Numerous epidemiological and clinical studies have shown that oxidative stress directly or indirectly contributes to the risk of lifestyle diseases ( - ), the strongest oxidizing agent in vivo ( According to recent research, oxidative and nitrosative stress plays a key role in the pathogenesis of respiratory (including asthma) and skin allergies (AD, urticaria) ( st century, which is why the role of oxidative, nitrosative and carbonyl stress in selected atopic diseases should be carefully scrutinized

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doi: 10.3390/ijms241311146 103 QiuLFengRWuQ-SWanJ-BZhangQ-W

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma