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Ultimately, the panelists emphasized, obesity is not the result of lifestyle choices but rather a disease that requires clinical intervention and should be viewed as a treatable disease

World J Gastroenterol 23(48):84658488 Amic F, Drmic D, Bilic Z, Krezic I, Zizek H, Peklic M et al (2018) Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine

So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load

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