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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Rhee S.G., Bae Y.S., Lee S.R., Kwon J

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This study elucidated the mechanism and relation of HIFs and MMPs indicating that increased vein wall tension induces HIFs overexpression and causes an increase in MMPs expression and reduction of venous contraction, leading to progressive venous dilation which may contribute to varicose vein formation (Figure 3) [91]