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Another study found that IFN- downregulates melanin regulators (DCT, KITLG, FZD5), leading to decreased melanin production in melanocytes, and promotes lipid peroxidation (ROS) and ferroptosis in primary melanocytes derived from patients

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Our findings, mirror the differences of Stage 2 or Stage 3 siblings when independently measured and show dramatic and statistically significant reductions of GPx3 in the most severely affect children ( p = 2.47 10 8 , Paired t-test) again with non-overlapping 95% confidence intervals (95% CI Unaffected Stage 2/3 [1.7 ug/ml, 2.1 ug/ml], 95% CI Konzo Stage 2/3 [0.98 ug/ml, 1.3 ug/ml]) (Fig