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Riboflavin role in migraine therapy is prophylactic, in other words, it affects migraine attacks frequency, severity, duration, and related disability, and facilitates acute therapies of migraine attacks (100)
Long-term safety data: not available for any duration or route of administration in humans
On the other hand, modern research classifies it as an adaptogen, known for helping regulate the bodys stress response through mechanisms like the HPA axis
doi:10.1074/jbc.273.42.27580
