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According to Ross and Siegel (2021) it is both triggered by the aromatic hydrocarbon receptor (AhR) directed response pathway and induced as a component of the Nrf2-mediated cellular stress response 38

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Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS

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Low-grade systemic inflammation driven by several mediators previously debated, such as LPS, bacterial translocation and the increased proinflammatory cytokines and Th1 response, are all contributing to an immunological response in the brain [139]