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Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

Heald AH, Sharma R, Anderson SG, Vyas A, Siddals K, Patel J, Bhatnagar D, Prabharkaran D, Rudenski A, Hughes E, Durrington P, Gibson JM, Cruickshank JK

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Regarding fatty acid metabolism, EGCG specifically binds to the ketone acyl reductase domain of FASN via its unique galloyl group, effectively inhibiting the enzyme's catalytic activity
