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This decreased availability of reducing power in Nrf2 / mice will not only negatively affect lipogenesis and nucleic acid synthesis, but will also contribute to reduced antioxidant availability in the cell, as NADPH acts as a reducing factor for both the GSH and the TXN systems
The gut microbiome of patients with COVID-19 has impaired SCFA biosynthesis ability
The recipient mice were treated with tamoxifen, which leads to the activation of Cre recombinase activity and subsequent deletion of Gclc specifically in the implanted tumours (Fig
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