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Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)

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Akt phosphorylates Thr and Ser in a sequentially dependent manner, thus activating downstream effectors (He et al., 2021

Long-Term Safety Considerations The absence of long-term human safety data represents the most significant knowledge gap around BPC-157