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The therapeutic dose is approximately 300-fold below the toxic threshold according to animal studies
Cancer cells use precursors derived from the TCA cycle intermediates to synthesize proteins, lipids, and nucleic acids
Excess IL-4 and IL-13 induce IgE class switching, which has been associated with the severity of lupus (116)
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demonstrated that tumors produce ammonia through glutamine metabolism, which is converted into glutamate and downstream amino acids via reductive amination to support cellular nitrogen requirements
