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236 The depletion of PGAM5 accelerates senescence via mitochondrial hyperfusion, reduces mitochondrial turnover, and increases ATP levels, ROS production, and mTOR activity via the downregulation of AMPK and TSC2

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Many of these substances show potential for industrial use and demand more research

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Mease PJ, Gottlieb AB, van der Heijde D, FitzGerald O, Johnsen A, Nys M, Banerjee S, Gladman DD (2017) Efficacy and safety of abatacept, a T-cell modulator, in a randomised, double-blind, placebo-controlled, phase III study in psoriatic arthritis

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