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Mol Neurobiol (2019) 56:7097112

[26] He has also tried incorporating ice baths, infrared light therapy, and LSD-microdosing into his routines, performing numerous experiments on himself to advance his studies and practices in anti-aging

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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder