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Both semaglutide and lipotropic compounds increase metabolic turnover and fluid demand

HL can also impact on HDL metabolism independent of its lipolytic properties, as adenovirus-mediated overexpression of catalytically inactive HL in HL knockout mice led to a reduction in plasma HDL levels, though to a lesser extent than observed in mice overexpressing similar levels of wild-type HL [5]
J Bacteriol 2013