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The 2026 Evidence for Kisspeptin in PMOS A landmark 2024 pre-clinical study published in Human Reproduction found that targeted inhibition of ARC kisspeptin-expressing neurons in a mouse model of PMOS lowered LH pulse frequency and restored normal androgen concentrations

doi: 10.1136/jitc-2022-005660 177 LowryBSJonusHCLeeJSpencerTHKenneyAMGoldsmithK

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In the study by Sun and colleagues, the A allele of this variant was found to be associated with increased levels of MDA and ROS, which can impair cell membrane fluidity and contribute to liver damage [271]

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