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2023;95:e28852

Other significant risk factors that may be linked to cognitive impairment include increased oxidative stress and inflammation [74], decreased physical activity [75], peripheral vascular disease [76], high or low blood pressure (non-normotensive patients) [77], elevated intracranial pressure linked to the narrowing of blood vessels in the brain [78], coexisting comorbidities [79], tobacco use [80], and genetic predisposition [81]

Presently, there are a total of four proposed transport models associated with flavonoids, namely glutathione S -transferase (GST), multidrug and toxic compound extrusion (MATE), multidrug resistance-associated protein (MRPs), and bilitranslocase-homolog (BTL)
