glutathione thiol pka values Species-Specific Standard Redox Potential of Thiol-Disulfide Systems: A Key Parameter to Develop Agents against Oxidative Stress The Multifaceted Role of Glutathione

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A critical gap is the identification of definitive molecular switches that determine whether the crosstalk promotes tumor cell survival or death in a given therapeutic setting, which severely impedes the rational design of pathway-specific modulators

doi: 10.1038/nature11011

Influence of ageing on the pharmacodynamics and pharmacokinetics of chronically administered medicines in geriatric patients: a review