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Further, it might be involved in appetite regulation, sleep improvement and age-related decline

Apply firm pressure for 2-3 minutes

Unlike other vitamins, absorption of vitamin B12 depends on a protein produced in your stomach, called intrinsic factor

(full study link in comments below) Also, this paragraph from #Katzungs_basic_and_clinical_pharmacology, 16th edition (2023), page 798: (the paragraph's picture is in comments) [[[[ Metformin interferes with the calcium-dependent absorption of vitamin B12-intrinsic factor complex in the terminal ileum, and vitamin B12 deficiency can occur after many years of metformin use

10.1371/journal.ppat.1005557