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341 Schwann cell injury In DPN, hyperglycemia and oxidative stress lead to Schwann cell dysfunction and apoptosis, resulting in demyelination and impaired nerve conduction

In another study, abnormal methylation was found within the gene promoters related to imprinting, spermatogenesis as well as defense system of antioxidant sort in the sperm of patients having impaired sperm DNA integrity status (Reference Song, Wang and Chen23)

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Given that lipophagy supplies FAs to boost FAO and TCA in mitochondria, we then reasoned that loss of LEC-autophagy could result in a concomitant downregulation of CPT1A levels, further impairing the overall capacity of the LEC to utilize FAs as energy source