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10.1128/jvi.00754-17 91

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In OA research, recent evidence indicates that pharmacological activation of the Nrf2GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Wu et al., 2025b

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Not when taken at recommended doses in healthy individuals

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Agrobacterium radiobacter (403) and other bacteria (404409) contain an ergothionase that degrades ERG to thiolurocanic acid (3-(1H-imidazol-5-yl)prop-2-enethioic S-acid) and trimethylamine, also implying that such cells possess one or more transporters for ERG

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Cancer 106 (1), 189198

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