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A phase 2 trial published in The Lancet gave retatrutide at doses between 4 mg and 12 mg once weekly to patients with confirmed insulin resistance

Jala, V

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doi: 10.1080/19490976.2025.2477255

These signals, in turn, can modulate calcium channels on the endoplasmic reticulum (ER), and prolonged dysregulation of this feedback loop increasingly contributes to calcium signaling abnormalities resembling those observed in the AD phenotype (Gibson et al., 2012)