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215 With age, the reduced pool of nave T cells may impair the ability of the immune system to detect these antigens, creating what is referred to as holes in the repertoire. This limitation could reduce the effectiveness of immunotherapies targeting neoantigens

The New England Journal of Medicine Testosterone Trials further demonstrated improvements in sexual function, physical function, and vitality in men over 65 with low testosterone (Snyder et al., 2016)

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PLoS Pathog 11(3):e1004676 Strandmark J, Steinfelder S, Berek C, Khl AA, Rausch S, Hartmann S (2017) Eosinophils are required to suppress Th2 responses in peyers patches during intestinal infection by nematodes