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EPA typically provides more anti-inflammatory benefits, while DHA supports cellular structure and function

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J Mol Biol 291(4):913926

Apparently, the B12 deficiency is keeping her system from producing enough new/developing blood cells, and those that were made were too large & disformed

If that's the case, switch over to a serum that contains bakuchiol, like the Paula's Choice Clinical Discoloration Repair Serum