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To date, there is only one approved medication available to treat ALS, namely riluzole, which only increases survival by 3 months (Bensimon et al., Energy metabolism disturbances in ALS There are many lines of evidence for the role of disturbed energy metabolism in ALS pathogenesis

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AGPCRs play a role in cell-cell adhesion and neuron guidance via different proteins present in the surface of the cells and play a role in the development of glutamatergic synapses in the cortex
