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Description
During hypoxia or under certain oncogenic conditions, -ketoglutarate could be converted directly to citrate (following a reversed TCA cycle), in order to generate the cytosolic acetyl-CoA when glucose-derived acetyl-CoA is insufficient [34]

doi: 10.1523/JNEUROSCI.4070-11.2012

This transition usually coincides with the dose escalation past 7.5mg, when the injection volume from the lower concentration exceeds practical syringe limits

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Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis
