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Acne: In some cases, B12 injections have been linked to breakouts

doi: 10.1038/clpt.2009.167

The physiology of glucagonlike peptide 1
Recombinant human insulin-like growth factor-I enhances whole body protein anabolism and significantly diminishes the protein catabolic effects of prednisone in humans without a diabetogenic effect
This includes: People with Pernicious Anemia: An autoimmune condition that prevents the absorption of B12 from the gut