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alternate supplement formulations of vitamin B 12 , such as methylcobalamin and hydroxycobalamin, have been suggested for this patient population

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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)

Injection bypasses first-pass hepatic metabolism and gastrointestinal absorption variability, potentially achieving higher bioavailability

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