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The compound originated at Monash University in Melbourne, Australia, and was developed commercially by Metabolic Pharmaceuticals Limited

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Small molecule derivatives of 4-amino-quinoline, in particular, are non-covalent and demonstrate an IC50 values in the nanomolar range (103, 104) and include three lead compounds: 78c (IC50 7.3 nM), 1ai (IC50 46 nM), and Iah (IC50 115 nM)