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NHS guidance on vitamin B12 says theres not enough evidence to show what the effects may be of taking high doses of vitamin B12 supplements each day, and therefore you should not take more than has been advised by your doctor

CRC Press, Boca Raton, pp 149165 Hunter RS (1975) Scales for measurements of color differences

S-Glutathionylation occurs extensively in diseases characterized by oxidative stress, including cardiovascular diseases, cancer, lung diseases, neurodegenerative diseases, and cancer

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect