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Biochemical Journal, 1965, 94(3): 705
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(1) Elongation of the side chain of amino acids
Interestingly, the first step in de novo pyrimidine biosynthesis mediated by CPSs occurs mainly in mitochondria via CPS1 in K-Ras/LKB1-mutant lung cancer cells 32 (Fig
This suggests that LCS3 does not compete directly with the cellular substrates of these enzymes in their free state, but rather inhibits the enzymes following the formation of an enzyme-substrate complex (34)
