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This disruption of the normal equilibrium between hepatocyte and its microenvironment (i.e., in particular with Kupffer cells and hepatic stellate cells, the latter promoting fibrogenesis) seems to determine the degree of hepatocyte injury and the triggering of downstream pathways that lead to cirrhosis, as reviewed in-depth elsewhere (70)

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ZSWIM8-Twin-Strep was cloned into pFLN

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Statistics The data of the three replicates were analyzed using two-way ANOVA (with the presence (+) or absence () of Al as independent factors)