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p=0.003) Discussion Since the first report of the neurotoxicity of the copper chelator cuprizone in Swiss albino mice by Carlton in 1966 (Carlton, 1966) and the subsequent early description of CPZ-induced OL death and demyelination in the superior cerebellar peduncles of ICI mice (Blakemore, 1972), the CPZ-induced demyelination model has been intensively studied and optimized for more than five decades (Vega-Riquer et al., 2019)

Cells were treated with LL-341070 or LL-341070A (in 0.4% DMSO) in duplicates with drug concentrations ranging from 0.031 to 10000 nM in half-log dilutions

Maintaining the optimal balance between reduced and oxidized GSH within cell compartments is essential for preserving cellular redox homeostasis 45

According to the authors, these results were unexpected, especially considering that previous studies yielded positive outcomes

Think of it like this: you wouldn't just buy a high-performance engine and drop it into your car without knowing how to connect it