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Considering that the human APOE isoform further regulates A clearance efficiency, and that sex and age modulate APOE-related AD risk via hormonal and aging factors (Valencia-Olvera et al., 2023)
Starting with a small dose and slowly increasing it helps avoid side effects
doi: 10.3390/nu12102929
Ageing 20 , 70 (2023)
In addition, inhibition of vesicular protein transport blocked the mitogenic effect of IGF-1, suggesting that IGF-1 can induce the secretion of some neurotrophic molecule important for cell proliferation
