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As tau becomes hyperphosphorylated, its capacity to support microtubule assembly and stability diminishes, resulting in increased levels of unbound tau that may aggregate into tangles (if not secreted or degraded in the lysosome) [107]

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doi: 10.1093/cercor/9.2.110

Additionally, temperature fluctuations can reduce its effectiveness, making it less effective at controlling blood sugar or aiding in weight loss

As a consequence, UK-5099 treatment sensitized T315I-Bcr-Abl-32D to JMF4073 but not 32D progenitor cells (Fig