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[DOI] [Google Scholar] Samuels M.H

While tirzepatide is a dual GLP-1/GIP agonist, cagrilintide acts via the amylin system

Large doses of folic acid given to an individual with an undiagnosed vitamin B 12 deficiency can correct megaloblastic anemia without correcting the underlying vitamin B 12 deficiency, leaving the individual at risk of developing irreversible neurologic damage (21)

The incidence is slightly higher than with semaglutide (13%) due to tirzepatides dual GIP and GLP-1 receptor agonism, which creates more pronounced metabolic and autonomic nervous system shifts

Continued therapy may be needed to sustain the benefits achieved over time