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Risbud et al
Cancer Cell (2006) 10:24152

In addition, grapefruit juice and orange juice made from Seville oranges may interact with sildenafil, potentially increasing its effects (Jetter, Clin Pharmacol Ther 2002

Furthermore, microcrystalline urate deposition activates the NLRP3 inflammasome in renal and vascular tissues, exacerbating kidney disease and cardiovascular complications through IL-1-mediated inflammation (Wang Q

Among these, ROS overproduction may be considered an important bridge between the two
