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In recent years, many bioinformatics analyses have identified ACSL1 as an indicator of active fatty acid metabolism and ferroptosis, indicating that it can also be a biomarker for predicting the prognosis of cancers and recognizing the phenotype of the tumor environment (TME) [119,120,121]

Abbreviations: Acknowledgements The authors would like to thank Dr

There have also been studies demonstrating the key roles of other amino acids in the regulation of T cells ( in vitro treatment with SAM or MTA promoted the expression of exhaustion marks, inhibited IFN- expression, and caused a closed chromatin structure in human CD8+ T cells ( MAT2A knockout protected tumor-infiltrating CD8+ T cells from exhaustion in a syngeneic mouse tumor model ( Figure 2 Perspective on methionine metabolism in T cell immunotherapy Improving cancer immunotherapy by targeting the methionine cycle of T cells is an area that remains unexplored

SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of Estrogen receptor-positive breast cancer