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Moreover, the mitochondrial isozyme is required for the accumulation of normal mitochondrial folate pools
PCa cells and stromal components sustain a hypermetabolic state characterized by heightened dependence on glutamine and mTORC1-mediated suppression of autophagy, a process critical for oncogenesis, as evidenced by dysregulated autophagy-related genes (e.g., STK11/LKB1) upstream of mTORC signaling (198)
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More specifically, it serves as an essential cofactor in mitochondria for both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase [203]
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health
