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(PubMed) Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ

Sodium Accumulated in Glia During Glutamate Transport Increases Polyamine Dependent Block of K ir 4.1 Channels

Iron overload enhances LPO through Fenton chemistry, whereby free iron catalyzes hydrogen peroxide conversion into highly reactive hydroxyl radicals, promoting oxidative damage to cellular membranes

Pharmacological inhibition of MIF not only diminishes these suppressive functions but also drives a phenotypic shift in MDSCs, transforming them into immunostimulatory, dendritic cell (DC)-like cells

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