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Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection
Needle-like crystals in the mouse can be intracellular or extracellular and may be associated with intense eosinophilic epithelial cytoplasm and extracellular crystals of various sizes

Figure 3), which is thought to exert its toxicity through reacting with thiol groups (cysteine, glutathione, thiol moieties of proteins) in the cytoplasm ( Because PAT also possesses acute toxicity, teratogenicity, and mutagenicity properties at the same time (Figure 4)

Chin J Integr Med Cardio-Cerebrovascular Disease
