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The most logical conclusion towards the NET is that it's a terribly weak NRI, since no NRE has ever been recorded in existence, nor have DRE ever been recorded, and the only compound known to have SRE-effects is Tianeptine, a compound vastly different in chemical structure to NSI-189 - so, purely from a statistical stand-point, it's probably an NRI

In addition, multiple other factors directly or indirectly regulate cellular senescence, including the role of CAFs within TME, tetraspanin-8 (TSPAN8)+ myofibroblastic CAF (myCAF), and senescent neutrophils (140)

Nonetheless, the CNS-specific mechanisms of NAC are still only partially explored and warrant further targeted research