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Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, et al

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Clinical studies on DNA methylation-targeted therapy in cancer care As recorded on more than 1,000 clinical trials (41% Phase I, 49% Phase II, 9% Phase III, and 1% Phase IV) have investigated the effects of DNMT inhibitors over the years, either as monotherapy or in combination with existing therapeutic strategies for the treatment of various tumor types, particularly hematologic tumors (e.g., AML

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They introduced the response-to-injury hypothesis, positing that endothelial injury initiates atherogenesis [9]
