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For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle
Nguyen, Q
& Gomes, A
10.1002/smll.202307273 71 VaghasiyaK.RayE.SinghR.JadhavK.SharmaA.KhanR.et al (2021)
Some of my younger patients have had their starting dose of Testosterone Cypionate carefully titrated down to just 5mg daily (3.5mg if you take out the ester attached to the Testosterone molecule), in order to keep them within normal physiological parameters and optimal well-being
