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Roy Turner officiating

Additional information The original online version of this article was revised: Acknowledgement section has been updated

The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETF-DH) gene

Although these disorders differ fundamentally from mitochondrial myopathies in their primary metabolic defects, involving cytosolic glycolysis or beta-oxidation rather than mitochondrial oxidative phosphorylation, they share a similar vulnerability to exercise-induced energy depletion, which provides a useful comparative framework

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