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Think Long-Term: Real cellular change happens over months, not days

Since most of the physiological properties of the GL are determined by the degree of GAG sulfation, ways to optimise inorganic sulfate, the rate-limiting substrate for sulfation, should be the primary focus of treatment

Hence, each continent and geographical region is associated with a distinctive array of mtDNA sequence types

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As expected (70), these diagnoses do not seem to follow predictable Mendelian patterns, suggesting that there are multiple genes and alleles that increase the risk of developing ME/CFS (56)