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Description
The addition of NAC to pirfenidone did not significantly affect the safety and tolerability profile of pirfenidone, but it did not appear to confer further benefits in terms of forced vital capacity, although it must be acknowledged that the study was underpowered to demonstrate a meaningful difference

Pu F, Chen F, Zhang Z, Shi D, Zhong B, Lv X, Tucker AB, Fan J, Li AJ, Qin K, Hu D, Chen C, Wang H, He F, Ni N, Huang L, Liu Q, Wagstaff W, Luu HH, Haydon RC, Shen L, He T-C, Liu J, Shao Z
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Angiogenic Pathway Studies: Used in research exploring vascularization mechanisms in controlled systems
Invest Dermatol 125 , 421427 (2005)
